SUPERSENSITIVITY TO CATECHOLAMINES FOLLOWING GUANETHIDINE
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چکیده
منابع مشابه
Influence of reserpine and guanethidine on the responses of the isolated rat ileum to catecholamines.
The sensitivity of the isolated ileum of the rat to catecholamines has been investigated using normal, reserpinized and guanethidine treated animals. Both reserpine and guanethidine treatment produces supersensitivity to adrenaline, noradrenaline and to a greater extent to isoprenaline.
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A patient is described who developed symptomatic sinus bradycardia as low as 20 beats per minute and sinus arrest of up to 4.4 seconds while receiving guanethidine, 75 mg daily. Tbe bradycardia resolved following discontinuation of the drug and reappeared upon challenge with i t Intrinsic disease of the sinoatrial and atrioventricular nodes was evidenced 3 weeks following discontinuation of tbe...
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SIR, Thank you for allowing me the opportunity to reply to Dr Simons's letter. Perhaps I may answer, one by one, the points he raises. Firstly, we cannot say that those in our sample who presented before 31/2, almost inevitably with a cosmetically noticeable squint, would necessarily have done so in other socioeconomic conditions. The particular set-up we have in that part of our district could...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology and Chemotherapy
سال: 1967
ISSN: 0366-0826
DOI: 10.1111/j.1476-5381.1967.tb02151.x